Markus Müschen
Markus Müschen
Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology; Director, Center of Molecular and Cellular Oncology; Chief, Cellular and Molecular Oncology
Yale School of Medicine
Elected to the Academy in 2023


Heinrich-Heine-Universität Düsseldorf (Germany), 1991-1998, Medicine; Université de Nantes, INSERM (Nantes, France), 1995, Immunology; Unité de Biologie Moléculaire, Institut Pasteur, (France), 1997, Molecular Biology; Heinrich-Heine-Universität Düsseldorf, 2000, MD;

Institute of Genetics, Universität zu Köln (Germany), 2003, MD/PhD, Immunology

Professional Area

Lymphocyte development, B- and T-cell antigen receptor signaling, leukemia, lymphoma, signal transduction, PI3K signaling, cell size regulation, mitochondrial biogenesis, energy metabolism, autoimmune diseases, cytokine receptor signaling, cell engineering, optogenetics


For fundamental contributions to understanding mechanisms of malignant transformation and clonal evolution towards B-cell leukemia and lymphoma, uncovering negative B-cell selection mechanisms in the immune system that are designed to clear autoreactive B-cells and how these mechanisms can be harnessed to overcome drug-resistance in refractory autoimmune diseases and B-cell malignancies.