Education
State University College of New York at Buffalo, 1986, BA, Biology; Rensselaer Polytechnic Institute, 1989, MS, Biology; Cornell University, 1993, PhD, Immunology.
Professional Area
Role of costimulation and adjuvants in T cell activation, effector differentiation and survival; T cell receptor independent activation of T cells by IL-1 cytokines in combination with common gamma chain cytokines; studies of T cells in acute lung injury and atherosclerosis in mouse models; use of proteomics for biomarker discovery.
Citation
Internationally recognized in the field of T cell immunobiology; pioneering work demonstrated that a specific combination of T cell costimulation induced anti-tumor responses and long-lasting immunity; Applied this principal of T cell costimulation to other fields including cardiovascular disease, acute lung injury and metabolism.