Mark W.  Hochstrasser
Mark W. Hochstrasser
Eugene Higgins Professor, Molecular Biophysics & Biochemistry, and Professor, Molecular, Cellular & Developmental Biology, Yale School of Medicine
Elected to the Academy in 2021


Rutgers University, 1981, BA, Biochemistry and German University of California – San Francisco (UCSF), 1987, Ph.D., Biochemistry.

Professional Area

Leader in the ubiquitin field, having made fundamental contributions to our understanding of the ubiquitin- proteasome system, an area of great clinical importance. Research combines elegant genetic experiments with imaginative biochemical and cell biological methods to understand ubiquitin-proteasome system mechanisms and how they are regulated in cells.


For fundamental contributions in identifying the first physiological substrate of the ubiquitin-proteasome system and determination of key features of substrate ubiquitylation and deubiquitylation, and of proteasome assembly; linked ubiquitylation dynamics with endosomal protein sorting; identified the first SUMO proteases; discovered a deubiquitylase used by intracellular Wolbachia bacteria to manipulate host reproduction.