Education
University of Oxford, Hertford College, 1988, BA, Biochemistry; Yale University, 1990, MPhil, Molecular Biophysics & Biochemistry; 1993, PhD, Molecular Biophysics & Biochemistry
Professional Area(s)
Molecular mechanism and recognition in cell signaling; use of structural biology, biochemical and biophysical approaches to elucidate the molecular regulatory principles of how receptor tyrosine kinases signal; laboratory determined the first crystal structure of the inactive state of EGFR’s extracellular region and used biophysical and biochemical tools to understand allosteric EGFR regulation by growth factors and its alteration by cancer mutations
Citation
Elucidated molecular mechanisms governing key cellular signaling processes and showed how epidermal growth factor receptor is allosterically regulated by different growth factors and mutations to direct distinct signals. Seminal contributions also revealed how modular protein domains recognize membrane components to organize signaling pathways.